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Proc-Type: 2001,MIC-CLEAR
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<SEC-DOCUMENT>0000902664-98-000046.txt : 19980210
<SEC-HEADER>0000902664-98-000046.hdr.sgml : 19980210
ACCESSION NUMBER:		0000902664-98-000046
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		19980209
SROS:			NASD

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CYTOTHERAPEUTICS INC/DE
		CENTRAL INDEX KEY:			0000883975
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				943078125
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		
		SEC FILE NUMBER:	005-42389
		FILM NUMBER:		98525162

	BUSINESS ADDRESS:	
		STREET 1:		2 RICHMOND SQUARE
		CITY:			PROVIDENCE
		STATE:			RI
		ZIP:			02906
		BUSINESS PHONE:		4012723310

	MAIL ADDRESS:	
		STREET 1:		2 RICHMOND SQUARE
		CITY:			PROVIDENCE
		STATE:			RI
		ZIP:			02906

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ARDSLEY ADVISORY PARTNERS
		CENTRAL INDEX KEY:			0000900529
		STANDARD INDUSTRIAL CLASSIFICATION:	 []
		IRS NUMBER:				0
		STATE OF INCORPORATION:			CT
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		646 STEAMBOAT ROAD
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830

	MAIL ADDRESS:	
		STREET 1:		CHRISTINE Y HOMER
		STREET 2:		900 THIRD AVENUE
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<TEXT>

                 SECURITIES AND EXCHANGE COMMISSION
                       Washington, D.C. 20549
                          ________________

                            SCHEDULE 13G/A
                          ________________

       INFORMATION STATEMENT PURSUANT TO RULES 13d-1 AND 13d-2
              UNDER THE SECURITIES EXCHANGE ACT OF 1934

                         (AMENDMENT NO. 4)*

                       CytoTherapeutics, Inc.

                          (NAME OF ISSUER)

                    Common Stock, $.01 par value

                   (TITLE OF CLASS OF SECURITIES)

                             232923 10 2

                           (CUSIP NUMBER)






__________________

*    The remainder of this cover page shall be filled out for a reporting
     person's initial filing on this form with respect to the subject class
     of securities, and for any subsequent amendment containing information
     which would alter the disclosures provided in a prior cover page.

     The information required in the remainder of this cover page shall not
     be deemed to be "filed" for the purpose of Section 18 of the Securities
     Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of
     that section of the Act but shall be subject to all other provisions of
     the Act (however, see the Notes).

                         PAGE 1 OF 5 PAGES 
<PAGE




                                 13G/A

CUSIP No.  232923 10 2
_____________________________________________________________________________
     (1)  NAME OF REPORTING PERSON 
          S.S. OR I.R.S. IDENTIFICATION NO. 
          OF ABOVE PERSON 
           Ardsley Advisory Partners
_____________________________________________________________________________
     (2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP ** 
                                                                    (a)  [ ] 
                                                                    (b)  [x] 
_____________________________________________________________________________
     (3)  SEC USE ONLY 

_____________________________________________________________________________
     (4)  CITIZENSHIP OR PLACE OF ORGANIZATION 
           Connecticut
_____________________________________________________________________________

NUMBER OF      (5)  SOLE VOTING POWER 
                    0
SHARES         ______________________________________________________________

BENEFICIALLY   (6)  SHARED VOTING POWER
                    0
OWNED BY       ______________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER 
                    0
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER 
                    0
_____________________________________________________________________________
     (9)  AGGREGATE AMOUNT BENEFICIALLY OWNED
          BY EACH REPORTING PERSON 
          0
_____________________________________________________________________________
    (10)  CHECK BOX IF THE AGGREGATE AMOUNT 
          IN ROW (9) EXCLUDES CERTAIN SHARES **                          [ ] 
_____________________________________________________________________________
    (11)  PERCENT OF CLASS REPRESENTED 
          BY AMOUNT IN ROW (9)           
          0%
_____________________________________________________________________________
    (12)  TYPE OF REPORTING PERSON **
          IA
_____________________________________________________________________________
               ** SEE INSTRUCTIONS BEFORE FILLING OUT!

                          PAGE 2 OF 5 PAGES
<PAGE




                                 13G/A

CUSIP No.  232923 10 2
_____________________________________________________________________________
     (1)  NAME OF REPORTING PERSON 
          S.S. OR I.R.S. IDENTIFICATION NO. 
          OF ABOVE PERSON 
          Philip J. Hempleman
_____________________________________________________________________________
     (2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP ** 
                                                                    (a)  [ ] 
                                                                    (b)  [x] 
_____________________________________________________________________________
     (3)  SEC USE ONLY 

_____________________________________________________________________________
     (4)  CITIZENSHIP OR PLACE OF ORGANIZATION 
           United States
_____________________________________________________________________________

NUMBER OF      (5)  SOLE VOTING POWER 
                    0
SHARES         ______________________________________________________________

BENEFICIALLY   (6)  SHARED VOTING POWER
                    0
OWNED BY       ______________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER 
                    0
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER 
                    0
_____________________________________________________________________________
     (9)  AGGREGATE AMOUNT BENEFICIALLY OWNED
          BY EACH REPORTING PERSON 
          0
_____________________________________________________________________________
    (10)  CHECK BOX IF THE AGGREGATE AMOUNT 
          IN ROW (9) EXCLUDES CERTAIN SHARES **                          [ ] 
_____________________________________________________________________________
    (11)  PERCENT OF CLASS REPRESENTED 
          BY AMOUNT IN ROW (9)           
          0%
_____________________________________________________________________________
    (12)  TYPE OF REPORTING PERSON **
           IN
_____________________________________________________________________________
               ** SEE INSTRUCTIONS BEFORE FILLING OUT!

                          PAGE 3 OF 5 PAGES
<PAGE



           The Schedule 13G initially filed for the year ended Dec. 31, 1993 
of (i) Ardsley Advisory Partners and (ii) Philip J. Hempleman relating to the 
common stock, par value of $.01 per share (the "Common Stock"), issued by 
CytoTherapeutics, Inc. (the "Company") is hereby amended by this Amndmt.No. 4 
to the Schedule 13G as follows:

ITEM 4.    OWNERSHIP.

           Not applicable.

ITEM 5.   OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.

          If this statement is being filed to report that as of the date 
hereof the reporting person has ceased to be the beneficial owner of more than 
five percent of the class of securities, check the following [x]




                                  PAGE 4 OF 5 PAGES

<PAGE>







ITEM 10.   CERTIFICATION.  (if filing pursuant to Rule 13d-1(b))

           By signing below Ardsley Advisory Partners and Philip J. Hempleman 
certify that, to the best of their knowledge & belief, the securities referred 
to above were acquired in the ordinary course of business, were not acquired to 
the purpose of and do not have the effect of changing, influencing the control 
of the issuer of such securities and were not acquired in connection with or
 as a participant in any transaction having such purposes or effect.




                              SIGNATURE

           After reasonable inquiry and to the best of their knowledge and 
belief, the undersigned certify that the information set forth in this statement
is true, complete and correct.




                                February __, 1998



                                /s/Philip J. Hempleman
                                -----------------------
                                Philip J. Hempleman, as
                                Managing Partner of 
                                Ardsley Advisory Partners




                                /s/Philip J. Hempleman
                                ------------------------
                                Philip J. Hempleman


                          PAGE 5 OF 5 PAGES

</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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